書誌： Physiology & Behavior ,2012
Physiology & Behavior 105 (2012) 536–543
Cheng-Hsien Lin, Ken Tokizawa , Mayumi Nakamura , Yuki Uchida b, Hisae Mori , Kei Nagashima
We evaluated the effect of plasma hyperosmolality on behavioral thermoregulation in mice, using a new experimental system. The system consisted of Plexiglas box (dimensions: 50 ×12 × 19 cm) with five computercontrolled Peltier boards (dimensions: 10 × 10 cm) at the bottom. Experiments were conducted in two different settings of the system. An operant behavior setting: each board was first set to 39 °C, and the right-endboard was changed to 20 °C for 1 min when a mouse moved to a specific position. A temperature mosaic setting: each board was randomly set to 15 °C, 22 °C, 28 °C, 35 °C, or 39 °C with a 6-min interval, but each boardtemperature was different from the others at a given time point. Mice were injected subcutaneous (s.c.)isotonic or hypertonic saline (154 mM (IS group) or 2,500 mM (HS group), 10 ml/kg body wt), and exposedto either setting for 90 min. In the operant setting, the HS group showed fewer operant behavior countsthan the IS group (11 ±5 and 25 ±4 counts, respectively; Pb0.05) with greater increase in body temperature(1.6 ±0.4 °C vs. 0.0 ±0.2 °C, respectively; Pb0.05). In the mosaic setting, the HS group selected the boardtemperature of 35 °C more frequently than the other temperatures (Pb0.05) with the same increase inbody temperature. These results may suggest that plasma hyperosmolality modulates behavioral thermoregulatory response to heat and induce regulated hyperthermia.