著者
柴田重信
所属
題材
被検体
マウス
データ収集方法
実験
専門分野
神経科学
評価指標
遺伝情報
キーワード
obesityhigh-fat dietmetabolic syndrome
概要

書誌:   Journal of Medicinal Chemistry , 2011

J. Med. Chem. 2011, 54, 6295–6304

Mayumi Okamoto,  Hiroyuki Irii, Yu Tahara, Hiroyuki Ishii, Akiko Hirao, Haruhide Udagawa, Masaki Hiramoto, Kazuki Yasuda, Atsuo Takanishi, Shigenobu Shibata, and Isao Shimizu

ABSTRACT: To determine the e ffects of a [6]-gingerol analogue (6G), a major chemical component of the ginger rhizome, and its stable analogueafter digestion in simulated gastric fluid, aza-[6]-gingerol (A6G), on diet-induced body fat accumulation, we synthesized 6G andA6G. Mice were fed either a control regular rodent chow, a high-fat diet (HFD), or a HFD supplemented with 6G and A6G.Magnetic resonance imaging adiposity parameters of the 6G- and A6G-treated mice were compared with those of control mice.Supplementation with 6G and A6G significantly reduced body weight gain, fat accumulation, and circulating levels of insulin andleptin. The mRNA levels of sterol regulatory element-binding protein 1c (SREBP-1c) and acetyl-CoA carboxylase 1 in the liver weresignificantly lower in mice fed A6G than in HFD control mice. Our findings indicate that A6G, rather than 6G, enhances energymetabolism and reduces the extent of lipogenesis by downregulating SREBP-1c and its related molecules, which leads to thesuppression of body fat accumulation.

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2015年02月02日 00:06
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