書誌： THE JOURNAL OF BIOLOGICAL CHEMISTRY ,2012
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 11, pp. 8318–8326, March 9, 2012
Yoshimi Uchida, Tomomi Osaki, Tokiwa Yamasaki, Tadanori Shimomura, Shoji Hata, Kazumasa Horikawa, Shigenobu Shibata, Takeshi Todo, Jun Hirayama, and Hiroshi Nishina
Background: MKK7 is a kinase involved in the cellular stress response. Results: MKK7 regulates circadian gene expression and the stability of an essential circadian component in unstressed mammalian cells. Conclusion: MKK7 functions as a circadian clock regulator. Significance: Our identification of role of MKK7 in the circadian clock provides insight into the importance of stress-responsive molecules in the maintenance of cellular homeostasis.