書誌： International Journal of Environmental Research Public Health,2010
Int. J. Environ. Res. Public Health 2010, 7, 4127-4138
Atsushi Mizukoshi, Kazukiyo Kumagai, Naomichi Yamamoto, Miyuki Noguchi, Kazuhiro Yoshiuchi, Hiroaki Kumano and Yukio Yanagisawa
Abstract: While various volatile organic compounds (VOCs) are known to show neurotoxic effects, the detailed mechanisms of the action of VOCs on the autonomic nervous system are not fully understood, partially because objective and quantitative measures to indicate neural abnormalities are still under development. Nevertheless, heart rate variability (HRV) has been recently proposed as an indicative measure of the autonomic effects. In this study, we used HRV as an indicative measure of the autonomic effrects to relate their values to thepersonal concentrations of VOCs measured by a real-time VOC monitor. The measurements were conducted for 24 hours on seven healthy subjects under usual daily life conditions.The results showed HF powers were significantly decreased for six subjects when the changes of total volatile organic compound (TVOC) concentrations were large, indicating asuppression of parasympathetic nervous activity induced by the exposure to VOCs. The present study indicated these real-time monitoring was useful to characterize the trends of VOC exposures and their effects on autonomic nervous system.
Keywords: real-time monitoring; VOCs; heart rate variability (HRV); Holter monitor