書誌： BioPsychoSocial Medicine ,2010
Ishizawa et al. BioPsychoSocial Medicine 2010, 4:1 http://www.bpsmedicine.com/content/4/1/1
Kaya T Ishizawa , Hiroaki Kumano , Atsushi Sato , Hiroshi Sakura, Yasuhiko Iwamoto
Abstract Background: This study was performed to examine whether patients with type 2 diabetes have cognitive deficitsassociated with the prefrontal cortex (PFC). Methods: Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controlsunderwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, andexecutive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin CardSorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance,performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as acovariate. Results: Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task(discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time inthe Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to thepresentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performancein the WCST. Conclusions: Our results showed that middle-aged, newly diagnosed and medication-free patients with type 2diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is anindependent effect of diabetes apart from being overweight.